MDLinx Infectious Disease – your first and best resource for the top literature, summarized and sorted to keep you current in just five minutes or less a day! Here, find exclusive content like highlighted articles you can’t miss from our physician editor D. Scott Cunningham, MD, PhD, and clinical pearls you can apply to your day to day, taken from recent Smartest Doc daily quiz competitions and Physician Reviews.
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1 Clinical and genetic determinants of plasma nevirapine exposure following an intrapartum dose to prevent mother-to-child transmission The Journal of Infectious Diseases, May 24, 2013 Clinical Article
2 Is it time to replace vancomycin in the treatment of methicillin-resistant Staphylococcus aureus infections Clinical Infectious Diseases, May 24, 2013 Clinical Article
3 Is azole resistance in aspergillus fumigatus a problem in spain? Antimicrobial Agents and Chemotherapy, May 24, 2013 Clinical Article
4 Activities of first-choice antimicrobials against gamma interferon-treated chlamydia trachomatis differ in hypoxia Antimicrobial Agents and Chemotherapy, May 24, 2013 Review Article
5 Heteroresistance to fosfomycin is predominant in streptococcus pneumoniae and depends on the mura1 gene Antimicrobial Agents and Chemotherapy, May 24, 2013 Clinical Article
6 Safety profile comparing azathioprine and mycophenolate in kidney transplant recipients receiving tacrolimus and corticosteroids Transplant Infectious Disease, May 24, 2013 Clinical Article
7 Staphylococcus aureus nasal carriage among injecting and non-injecting drug users and antimicrobial susceptibility Full Text American Journal of Infectious Diseases, May 24, 2013 Clinical Article
8 10 x 20 Progress--Development of New Drugs Active Against Gram-Negative Bacilli: An Update From the Infectious Diseases Society of America Clinical Infectious Diseases, May 23, 2013 Clinical Article
9 Differential penetration of raltegravir throughout gastrointestinal tissue: implications for eradication and cure AIDS, May 23, 2013 Clinical Article
10 Clinical trial: comparative effectiveness of cephalexin plus trimethoprim-sulfamethoxazole versus cephalexin alone for treatment of uncomplicated cellulitis: A randomized controlled trial Clinical Infectious Diseases, May 23, 2013 Clinical Article
11 Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations Clinical Infectious Diseases, May 23, 2013 Clinical Article
12 The use of steroids to prevent cutaneous reactions to benznidazole in patients with Chagas disease Pathogens and Global Health, May 23, 2013 Clinical Article
13 Use of rifamycin drugs and development of infection by rifamycin-resistant strains of clostridium difficile Antimicrobial Agents and Chemotherapy, May 23, 2013 Clinical Article
14 Rationale, design and organization of the delayed antibiotic prescription (DAP) trial: a randomized controlled trial of the efficacy and safety of delayed antibiotic prescribing strategies in the non-complicated acute respiratory tract infections in general practice Full Text BMC Family Practice, May 23, 2013 Clinical Article
15 Comparative activities of telavancin combined with nafcillin, imipenem, and gentamicin against staphylococcus aureus Antimicrobial Agents and Chemotherapy, May 23, 2013 Clinical Article
16 Identification and Characterization of a Novel HIV-1 Nucleotide-Competing Reverse Transcriptase Inhibitor Series Antimicrobial Agents and Chemotherapy, May 23, 2013 Clinical Article
17 Safety and tolerability of luliconazole solution 10-percent in patients with moderate to severe distal subungual onychomycosis Antimicrobial Agents and Chemotherapy, May 23, 2013 Clinical Article
18 Efficacy and safety of liposomal clarithromycin and its effect on pseudomonas aeruginosa virulence factors Antimicrobial Agents and Chemotherapy, May 23, 2013 Clinical Article
19 A combined pharmacodynamic quantitative and qualitative model reveals the potent activity of daptomycin and delafloxacin against staphylococcus aureus biofilms Antimicrobial Agents and Chemotherapy, May 23, 2013 Clinical Article
20 Human organic cation transporters 1 (slc22a1), 2 (slc22a2), and 3 (slc22a3) as disposition pathways for fluoroquinolone antimicrobials Antimicrobial Agents and Chemotherapy, May 23, 2013 Clinical Article
In a study involving 37 patients with chronic hepatitis B infections, a serum bilirubin level > 5 mg/dL was predictive of progression to hepatic failure and liver-related death.
Read the article summaryIn a study involving 1607 patients > 65 years of age with community- or healthcare-acquired pneumonia, pre-morbid ambulation impairment (OR=2.61), hospitalization within 30 days of acquiring pneumonia (OR=1.93), and absence of cough and purulent sputum (OR=1.47) were shown to be associated with a significant increase in 30-day mortality.
Read the article summaryIn a retrospective study involving 225 patients with esophageal squamous cell carcinoma (ESCC) and 224 matched controls, it was shown that patients who were HPV-positive and smoked cigarettes or smoked cigarettes plus consumed alcohol were at increased risk for ESCC than patients who were HPV-negative (OR = 2.22 and 10.31, respectively).
Read the article summary1 Infective Endocarditis New England Journal of Medicine, April 12, 2013
2 Early use of daptomycin versus vancomycin for methicillin-resistant Staphylococcus aureus bacteremia with vancomycin MIC>1 mg/L: a matched cohort study Clinical Infectious Diseases, March 15, 2013
3 Early Use of Daptomycin Versus Vancomycin for Methicillin-Resistant Staphylococcus aureus Bacteremia With Vancomycin Minimum Inhibitory Concentration >1 mg/L: A Matched Cohort Study Clinical Infectious Diseases, April 1, 2013
4 Clostridium Difficile Colitis: Review of the Therapeutic Approach American Journal of Therapeutics, April 8, 2013
5 Continuous versus intermittent infusions of antibiotics for the treatment of severe acute infections Cochrane Reviews, March 29, 2013 Review Article
6 Cobicistat Versus Ritonavir as a Pharmacoenhancer of Atazanavir Plus Emtricitabine/Tenofovir Disoproxil Fumarate in Treatment-Naive HIV Type 1-Infected Patients: Week 48 Results The Journal of Infectious Diseases, April 22, 2013
7 Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: meta-analysis of randomised controlled trials European Journal of Clinical Microbiology & Infectious Diseases, April 10, 2013 Evidence Based Medicine
8 Clustering of Antimicrobial Resistance Outbreaks Across Bacterial Species in the Intensive Care Unit Clinical Infectious Diseases, April 18, 2013
9 Clinical Trial: Comparative Effectiveness of Cephalexin Plus Trimethoprim-Sulfamethoxazole Versus Cephalexin Alone for Treatment of Uncomplicated Cellulitis: A Randomized Controlled Trial Clinical Infectious Diseases, April 3, 2013
10 Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach The Lancet Infectious Diseases, March 20, 2013
11 Adverse events associated with nevirapine use in pregnancy: a systematic review and meta-analysis AIDS, April 23, 2013 Evidence Based Medicine Review Article
12 Outcomes of Appropriate Empiric Combination versus Monotherapy for Pseudomonas aeruginosa Bacteremia Antimicrobial Agents and Chemotherapy, March 6, 2013
13 A Randomized Double-Blind Comparison of Coformulated Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate Versus Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate for Initial Treatment of HIV-1 Infection: Analysis of Week 96 Results Journal of Acquired Immune Deficiency Syndromes, April 17, 2013
14 Cobicistat: A New Boost for the Treatment of Human Immunodeficiency Virus Infection Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, March 13, 2013
15 Durable Efficacy and Safety of Raltegravir Versus Efavirenz When Combined With Tenofovir/Emtricitabine in Treatment-Naive HIV-1–Infected Patients: Final 5-Year Results From STARTMRK Journal of Acquired Immune Deficiency Syndromes, April 16, 2013
16 Linezolid versus vancomycin for meticillin-resistant Staphylococcus aureus infection: a meta-analysis of randomised controlled trials International Journal of Antimicrobial Agents, April 23, 2013 Evidence Based Medicine
17 De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock Cochrane Reviews, April 11, 2013 Review Article
18 Ampicillin Plus Ceftriaxone Is as Effective as Ampicillin Plus Gentamicin for Treating Enterococcus faecalis Infective Endocarditis Clinical Infectious Diseases, April 10, 2013
19 What is the Best Antimicrobial Treatment for Severe Community-Acquired Pneumonia (Including the Role of Steroids and Statins and Other Immunomodulatory Agents) Infectious Disease Clinics of North America, February 18, 2013
20 New antifungal antibiotics Current Opinion in Infectious Diseases, February 27, 2013
Indexed Journals in Infectious Disease: Journal of Infection, AIDS, American Journal of Infection Control more
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