Hospital readmission rate in patients discharged on parenteral antibiotics
As reported in Clinical Infectious Diseases, the hospital readmission rate for patients (n=782) discharged on parenteral antibiotics was 26%. The mean patient age was 58 years. The leading diagnoses were bacteremia, osteomyelitis, and pyelonephritis. The indications for readmission included non-infection related (30%), worsening symptoms (29%), and new infections (19%). The ORs for readmission factors were as follows: each decade increase in age, 1.09; aminoglycoside use, 2.33; resistant organism, 1.57; and number of hospital discharges in prior 12 months, 1.20.
Short-term valacyclovir therapy does not reduce HIV acquisition risk in HSV-2 infected women
As reported in the Journal of Infectious Diseases, short-term treatment of HSV-2 infected, HIV non-infected women (n=30) with valacyclovir (1 g qd x 2 months) had no effect on cervical CD4+ T cells, dendritic cells, or pro-inflammatory cytokines, but increased CCR5 (HIV co-receptor) and CD69 (activation marker).
Pre-treatment with EPA decreases incidence of IFN-?-induced depression
As reported in Biological Psychiatry, pre-treatment of HCV-infected patients (n=162) with EPA for 2 weeks resulted in a decreased incidence of IFN-α-induced depression at 24 weeks compared to placebo (10% vs. 30%), and a delayed onset of depression (12.0 weeks vs. 5.3 weeks).