1West Nile virus infection incidence based on donated blood samples and neuroinvasive disease reports, northern Texas, USA, 2012Emerging Infectious Diseases  Full Text  Clinical Article
2Donor-derived strongyloides stercoralis infection in solid organ transplant recipients in the United States, 2009-2013American Journal of Transplantation  Clinical Article
3La Crosse Virus in Aedes japonicus japonicus Mosquitoes in the Appalachian Region, United StatesEmerging Infectious Diseases  Full Text  Clinical Article
4Assessing the paradox between transmitted and acquired HIV type 1 drug resistance mutations in the Swiss HIV cohort study from 1998 to 2012The Journal of Infectious Diseases  Clinical Article
5The importance of clinical surveillance in detecting Legionnaires' disease (LD) outbreaks: A large outbreak in a hospital with a legionella disinfection system, Pennsylvania, 2011-2012Clinical Infectious Diseases  Clinical Article
6Female and male differences in AIDS diagnosis rates among people who inject drugs in large U.S. metro areas from 1993 to 2007Annals of Epidemiology  Clinical Article
7Multicenter experience using simeprevir and sofosbuvir with or without ribavirin to treat hepatitis C genotype 1 after liver transplantHepatology  Clinical Article
8Baseline prevalence and predictors of liver fibrosis among HIV-positive individuals: A substudy of the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trialHIV Medicine  Clinical Article
9Health economic evaluations of visceral leishmaniasis treatments: A systematic reviewPLoS Neglected Tropical Diseases  Full Text  Clinical Article
10Influence of lifelong cumulative HIV viremia on long-term recovery of CD4+ cell count and CD4+/CD8+ ratio among patients on combination antiretroviral therapyAIDS  Clinical Article
1Vaccines from a reactorMax-Planck-Gesellschaft Research news
2Advisory Committee on Immunization Practices (ACIP) reaffirms recommendation for annual influenza vaccinationCDC
3Largest study of its kind documents causes of childhood community-acquired pneumoniaUniversity of Utah Health Care
4Scientists uncover new role for neurotransmitter that helps fight infectionImperial College London Health News
5$2.5 million NIH grant to fund Mount Sinai research into reducing heroin injection and HIV infectionThe Mount Sinai Hospital
6TSRI team shows how rare antibody targets Ebola and Marburg virusesScripps Research Institute News
7Malaria transmission linked to mosquitoes' sexual biologyHarvard School of Public Health News
8HIV latency is not an accident: It is a survival tactic employed by the virusGladstone Institutes News
9Research captures transient details of HIV genome packagingRockefeller University News
10HIV controls its activity independent of host cellsNational Institute of Allergy and Infectious Disease - News

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Hospital readmission rate in patients discharged on parenteral antibiotics

As reported in Clinical Infectious Diseases, the hospital readmission rate for patients (n=782) discharged on parenteral antibiotics was 26%. The mean patient age was 58 years. The leading diagnoses were bacteremia, osteomyelitis, and pyelonephritis. The indications for readmission included non-infection related (30%), worsening symptoms (29%), and new infections (19%). The ORs for readmission factors were as follows: each decade increase in age, 1.09; aminoglycoside use, 2.33; resistant organism, 1.57; and number of hospital discharges in prior 12 months, 1.20.

Short-term valacyclovir therapy does not reduce HIV acquisition risk in HSV-2 infected women

As reported in the Journal of Infectious Diseases, short-term treatment of HSV-2 infected, HIV non-infected women (n=30) with valacyclovir (1 g qd x 2 months) had no effect on cervical CD4+ T cells, dendritic cells, or pro-inflammatory cytokines, but increased CCR5 (HIV co-receptor) and CD69 (activation marker).

Pre-treatment with EPA decreases incidence of IFN-?-induced depression

As reported in Biological Psychiatry, pre-treatment of HCV-infected patients (n=162) with EPA for 2 weeks resulted in a decreased incidence of IFN-α-induced depression at 24 weeks compared to placebo (10% vs. 30%), and a delayed onset of depression (12.0 weeks vs. 5.3 weeks).

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Clinical Pearls

Clinical Pearl from Smartest DocSimeprevir and sofosbuvir offer the potential for shorter and simpler regimens for hepatitis C virus infection.

Clinical Pearl from Smartest DocIn fast allen Studien wurden bei HIV-negativen Patienten höhere H. pylori-Raten gezeigt als bei HIV+ Patienten.

Clinical Pearl from Smartest DocESRD and chronic liver disease predict high vancomycin MIC in patients with community-onset MRSA bacteremia.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List