The Latest Clinical Articles in Infectious Disease

1Risk factors for fatal outcome from Rocky Mountain spotted fever in a highly endemic area-Arizona, 2002-2011Clinical Infectious Diseases, March 26, 2015  Clinical Article
2Antibiotic prevention of postcataract endophthalmitis: A systematic review and meta-analysisActa Ophthalmologica, March 26, 2015  Evidence Based Medicine  Review Article
3An evaluation of the level of agreement in Bordetella species identification in three United States laboratories during a period of increased pertussisJournal of Clinical Microbiology, March 26, 2015  Clinical Article
4HIV-1 fitness cost associated with escape from the VRC01 class of CD4 binding site neutralizing antibodiesJournal of Virology, March 26, 2015  Clinical Article
5Hepcidin/ferroportin expression levels involve efficacy of pegylated-interferon plus ribavirin in hepatitis C virus-infected liverWorld Journal of Gastroenterology, March 26, 2015  Full Text  Clinical Article
6Comparison of azithromycin plus chloroquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in children in Africa: A randomized, open-label studyMalaria Journal, March 26, 2015  Full Text  Clinical Article
7Suppression of SIRT1 activity in noncancerous tissues of HCC: possible association with non-B non-C hepatitis pathogenesisCancer Science, March 26, 2015  Clinical Article
8Do web-based and clinic samples of gay men living with HIV differ on self-reported physical and psychological symptoms? A comparative analysisJournal of Medical Internet Research, March 26, 2015  Full Text  Clinical Article
9Variations in Neisseria meningitidis carriage by socioeconomic status: A cross-sectional studyJournal of Public Health, March 26, 2015  Clinical Article
10Strong correlation between protein reagent strip and protein-to-creatinine ratio for detection of renal dysfunction in HIV-infected patients: A cross-sectional studyAIDS Research and Therapy, March 26, 2015  Full Text  Clinical Article
1WHO calls on the world to "Gear Up to End TB"WHO - World Health Organization, March 26, 2015
2WHO and World Food Programme join forces to reach zero Ebola casesWHO - World Health Organization, March 26, 2015
3American College of Physicians joins HHS in accelerating alternative payment methods through ‘Health Care Payment Learning and Action Network’ American College of Physicians News, March 26, 2015
4FDA Drug Safety Communication: FDA warns of serious slowing of the heart rate when antiarrhythmic drug amiodarone is used with hepatitis C treatments containing sofosbuvir (Harvoni or Sovaldi) in combination with another direct acting antiviral drugFDA What's New: Drugs, March 26, 2015
5First Ebola vaccine to be tested in affected communities one year into outbreak: Ring vaccination starts in Coyah, GuineaWHO news, March 26, 2015
6Peoples health at the centre of new global blueprint to reduce disaster risksWHO - World Health Organization, March 26, 2015
7For most children with HIV and low immune cell count, cells rebound after treatmentNIH News, March 25, 2015
8Johns Hopkins Bloomberg School of Public Health researchers receive grant to evaluate malaria detection testJohns Hopkins Bloomberg School of Public Health, March 23, 2015
9Increased susceptibility to measles: A side effect of Ebola epidemicJohns Hopkins Bloomberg School of Public Health, March 23, 2015
10WHO calls on the world to “Gear up to End TB”WHO news, March 20, 2015

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Intermittent ?-lactam bolus therapy less effective than prolonged infusion

Based on a meta-analysis (n=29 studies [2206 patients]) published in the Journal of Antimicrobial Agents, intermittent β-lactam therapy was less effective than prolonged infusion with respect to mortality rate (RR = 0.66) and clinical success (RR = 1.12).

Hospital readmission rate in patients discharged on parenteral antibiotics

As reported in Clinical Infectious Diseases, the hospital readmission rate for patients (n=782) discharged on parenteral antibiotics was 26%. The mean patient age was 58 years. The leading diagnoses were bacteremia, osteomyelitis, and pyelonephritis. The indications for readmission included non-infection related (30%), worsening symptoms (29%), and new infections (19%). The ORs for readmission factors were as follows: each decade increase in age, 1.09; aminoglycoside use, 2.33; resistant organism, 1.57; and number of hospital discharges in prior 12 months, 1.20.

HIV viremia associated with increased risk for NHL

As reported in Modern Pathology, CDX2 expression is associated with low-grade small intestinal adenocarcinomas, decreased nodal metastases, and decreased perineural invasion, while MUC1 expression is associated with high-grade tumors, and nodular and infiltrative tumors. The CDX2+/MUC1- immunophenotype is associated with increased survival.

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Clinical Pearl from Smartest DocHypokalemia and hypophosphatemia are indicators of proximal tubular dysfunction in HIV-infected patients.

Clinical Pearl from Smartest DocOne in every 12 to 13 men diagnosed with gonorrhea have persistent infection 2 weeks after starting treatment.

Clinical Pearl from Smartest DocDie Prävalenz der MRSA-Kolonisationen bei Dialysepatienten beträgt schätzungsweise 6,2 %.

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