Maalouf NM et al. – Osteoporosis is increasingly reported in the aging HIV–positive population, and co–infection with hepatitis C virus (HCV) may further increase the risk of osteoporosis. However, it remains unclear whether HCV–related increased fracture risk is a function of the severity of liver disease. Among HIV–infected patients, severity of liver disease partly explains the HCV–associated increased risk of osteoporotic fractures. Other determinants of this increased risk remain to be defined.