Multicenter Study of Voriconazole Pharmacokinetics and Therapeutic Drug Monitoring
Antimicrobial Agents and Chemotherapy, 08/21/2012
Dolton MJ et al. – Multiple regression analysis of voriconazole concentration identified associations between increasing patient weight, oral administration of voriconazole, and coadministration of phenytoin or rifampin and significantly reduced concentrations, and associations between increasing patient age and coadministration of proton pump inhibitors and increased concentrations. Coadministration of glucocorticoids was found to significantly reduce voriconazole concentrations, inferring a previously unreported drug interaction between glucocorticoids and voriconazole.