Safety of peginterferon alfa-2a plus ribavirin in a large multinational cohort of chronic hepatitis C patients
Liver International,  Clinical Article

Lee SS et al. – The study confirmed the safety and tolerability profile of peginterferon alfa–2aribavirin and identified patient subgroups at higher risk of dose reductions and discontinuations, thus allowing optimum management of adverse events (AEs).

Methods
  • Patients were assigned at the investigator's discretion to 24- or 48-week treatment with peginterferon alfa-2a 180 μg/week and ribavirin 800 mg/day or 1000/1200 mg/day.
  • All AEs, defined as SAEs and non-SAEs of special interest, were recorded during treatment and for 12 weeks thereafter.
  • Non-SAEs of special interest included those leading to dose reduction/discontinuation, neutropenia, thrombocytopenia, anaemia, ALT elevations leading to dose modification and unknown/unexpected AEs.

Results
  • Of 1675 and 7178 patients assigned to 24 and 48 weeks of treatment, respectively, 87.6 and 68.3% completed therapy, whereas 6.4 and 10.3% prematurely stopped peginterferon alfa-2a treatment because of AEs.
  • Among patients assigned to 24 and 48 weeks, 37.4 and 46.9%, respectively, reported any AE (SAE or non-SAE of special interest); 4.2 and 6.6% reported SAEs and 35.2 and 44.0% reported non-SAEs of special interest.
  • Female gender, increasing age and cirrhosis were significantly associated with dose reductions of either drug.
  • Increasing age (and female gender in the case of ribavirin) was significantly associated with treatment discontinuation.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Infectious Disease

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Infectious Disease Articles

1 Inhaled Ebola vaccine may offer long-term protection from virus The University of Texas at Austin News, November 7, 2014

2 Antibiotics get a time-out McGill University Health Centre News, November 20, 2014

3 Duke team brings life-saving function to ketchup packets Duke University Health & Medicine News, July 3, 2014

4 Colistin for the treatment of ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: A systematic review and meta-analysis International Journal of Antimicrobial Agents, October 7, 2014    Evidence Based Medicine    Review Article

5 Triatoma sanguisuga blood meals and potential for Chagas disease, Louisiana, USA Full Text Emerging Infectious Diseases, November 25, 2014    Free full text    Clinical Article

6 A systematic review: Can one prescribe carbapenems to patients with IgE-mediated allergy to penicillins or cephalosporins? Clinical Infectious Diseases, October 6, 2014    Review Article

7 Effectiveness of silver-impregnated central venous catheters for preventing catheter-related blood stream infections: A meta-analysis International Journal of Infectious Diseases, November 11, 2014    Evidence Based Medicine

8 Prolonged infusion versus intermittent boluses of β-lactam antibiotics for treatment of acute infections: A meta-analysis International Journal of Antimicrobial Agents, April 25, 2014    Review Article

9 Condoms are more effective when applied by males: a study of young black males in the United States Annals of Epidemiology , November 14, 2014    Clinical Article

10 Prediction model for 30-day hospital readmissions among patients discharged receiving outpatient parenteral antibiotic therapy Clinical Infectious Diseases, January 30, 2014    Clinical Article

11 Antibody persistence after primary and booster doses of a quadrivalent meningococcal conjugate vaccine in adolescents The Pediatric Infectious Disease Journal, October 31, 2014    Clinical Article

12 Adherence to HIV postexposure prophylaxis: A systematic review and meta-analysis AIDS, November 21, 2014    Evidence Based Medicine    Review Article

13 Antistaphylococcal penicillins versus cephalosporins for definitive treatment of methicillin-susceptible bacteraemia: A systematic review and meta-analysis International Journal of Antimicrobial Agents, September 30, 2014    Evidence Based Medicine    Review Article

14 Diagnostic accuracy of IL-2 for the diagnosis of latent tuberculosis: A systematic review and meta-analysis European Journal of Clinical Microbiology & Infectious Diseases, November 17, 2014    Evidence Based Medicine    Review Article

15 HIV: New drugs, new guidelines Current Opinion in Infectious Diseases, November 5, 2014    Review Article

16 Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: A randomized clinical trial JAMA, August 1, 2014    Clinical Article

17 Effectiveness of seasonal influenza vaccine in community-dwelling elderly people: A meta-analysis of test-negative design case-control studies The Lancet Infectious Diseases, November 7, 2014    Evidence Based Medicine

18 Prevalence, correlates, and outcomes of cryptococcal antigen positivity among AIDS patients, United States from 1986-2012 Clinical Infectious Diseases, November 26, 2014    Clinical Article

19 Global burden of transmitted HIV drug resistance and HIV-exposure categories: A systematic review and meta-analysis AIDS, November 24, 2014    Evidence Based Medicine    Review Article

20 Association between footwear use and neglected tropical diseases: A systematic review and meta-analysis Full Text PLoS Neglected Tropical Diseases, November 19, 2014    Free full text    Evidence Based Medicine    Review Article

Indexed Journals in Infectious Disease: Journal of Infection, AIDS, American Journal of Infection Controlmore