Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling
Journal of Leukocyte Biology, 08/10/2012
Ahmed KA et al. – The data suggest a new “dynamic model of three–cell interactions” for CTL immunity derived from stimulation by dissociated, licensed DCs, primed CD4+ T cells, and DC–CD4+ T cell clusters and may have significant implications for autoimmunity and vaccine design.



