Spectrum of Respiratory Viruses in Children With Community-acquired Pneumonia
The Pediatric Infectious Disease Journal, 07/27/2012
García–García ML et al. – The high prevalence of viral infections supports the role of respiratory viruses, mainly RSV, rhinovirus (RV), human metapneumovirus (HMPV) and human bocavirus (HBoV) in CAP of children requiring hospitalization. These findings help us to understand the etiologic disease burden and to guide research and public health policy.Methods
- A 6-year prospective study was conducted in children <14 years old admitted to the Pediatrics Department of the Severo Ochoa Hospital (Spain) with CAP.
- The authors studied the frequency of 16 respiratory viruses in nasopharyngeal aspirates. Clinical characteristics of respiratory syncytial virus (RSV)-only infections were compared with those of RV, HMPV and HBoV single infections.
- A viral pathogen was identified in 649 (73.4%) of 884 hospitalized children with CAP.
- Viral coinfections were detected in 30%. The rate of viral detection was significantly greater in infants <18 months (83%) than in older children (67%) (P < 0.001).
- The most frequently detected virus was RSV with 41.6% of positive patients followed by RV (26.2%), HBoV (17.8%), adenovirus (17.8%), HMPV (7%) and parainfluenza (7%).
- RSV was the most frequent virus in children <18 months, but RV was most common in the eldest group (P < 0.001).