Combination therapy for treatment of infections with gram-negative bacteria
Clinical Microbiology Reviews, 07/10/2012
Tamma PD et al. – The available evidence suggests that the greatest benefit of combination antibiotic therapy stems from the increased likelihood of choosing an effective agent during empiric therapy, rather than exploitation of in vitro synergy or the prevention of resistance during definitive treatment. In this review, they summarize the available data comparing monotherapy versus combination antimicrobial therapy for the treatment of infections with Gram–negative bacteria.