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Bacterial biofilms in the upper airway - evidence for role in pathology and implications for treatment of otitis media
Paediatric Respiratory Reviews, 06/29/2012
Bakaletz LO – The design of vaccine candidates for otitis media [OM] that currently focus on preventing colonization are predicated on the assumption that by reducing the burden of bacteria present in the pediatric nasopharynx, one could reduce or eliminate the likelihood of retrograde ascension of the Eustachian tube by bacteria from the nasopharynx to the middle ear. If effective, this strategy could prevent biofilms from ever forming in the middle ear.
