Late-onset Bloodstream Infections in Preterm infants: a Two-Year Survey
Pediatrics International, 06/12/2012
Grisaru–Soen G et al. – LO–BSIs frequently affect very low birthweight (VLBW) infants. Strategies to prevent LO–BSIs should target peripheral catheters.Methods
- The records of all preterm infants (<37 weeks gestation) born between 2004-2005 and hospitalized in NICU for >3 days were retrieved for this retrospective matched case-control study.
- 108 out of 1459 preterm infants (7.4%) had 142 episodes of LO-BSI.
- The highest LO-BSI rate (44%) was among 198 very low birthweight (VLBW) infants (<1500 g).
- The most common causative organisms were Coagulase-negative staphylococci and Klebsiella (60% and 13%, respectively).
- The mean hospital stay was 64 days for LO-BSI preterm infants versus 48 days for non-LO-BSIs preterm infants.
- Congenital malformations and peripheral catheters were independent risk factors for LO-BSIs.
- Crude mortality rates were 6.9% (LO-BSIs) and 3.0% (non-LO-BSIs), with an LO-BSI-attributable mortality of 3.9%.