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Diffuse large B-cell lymphoma in an adolescent female presenting with Epstein-Barr virus-driven hemophagocytic lymphohistiocytosis: a case report Full Text
Journal of Medical Case Reports, 06/04/2012
Altaf S et al. – Hemophagocytic lymphohistiocytosis is a rare disorder, but potentially lethal if not diagnosed and treated in a timely manner. The case highlights the importance of considering this diagnosis in critically ill patients who may not initially fulfill formal diagnostic criteria. In patients diagnosed with hemophagocytic lymphohistiocytosis, occult malignancies should be aggressively ruled out as they can be present prior to the hemophagocytic lymphohistiocytosis diagnosis or appear during the treatment phase. An accurate diagnosis is also important because management of Epstein–Barr virus–driven hemophagocytic lymphohistiocytosis and Epstein–Barr virus–driven lymphoma differs due to the difference in pathophysiology and the involvement of different immune cell lines
