Antibodies and carbohydrate ligands binding to C-type lectin DC-SIGN differentially modulate receptor trafficking
European Journal of Immunology, 06/04/2012
Tacken PJ et al. – DC–SIGN showed a poor ability to accumulate targeting Abs within DCs. Vaccine efficacy may therefore be enhanced by strategies increasing the amount of Ag entering via a single receptor molecule, such as the use of targeting moieties allowing DC–SIGN recycling or Ab–coated vaccine carriers.