Prevalence of HIV-1 integrase mutations related to resistance to dolutegravir in raltegravir naive and pretreated patients
Clinical Microbiology and Infection, 05/30/2012
Saladini F et al. – RTG–selected double and triple mutants, mostly the G140S/Q148H variant, were detected in only 32 (26.7%) RTG–treated patients. Since L101I and T124A do not appear to exert any major effect in vivo and double and triple mutants resistant to DTG are infrequently selected by RTG, DTG can be effectively used in INI–naïve patients and may retain activity in many patients failing RTG.