Human Galectin 3 Binding Protein Interacts with Recombinant Adeno-Associated Virus Type 6

Journal of Virology, 06/01/2012

Interaction of hu–G3BP with rAAV–6 led to the formation of aggregates and hampered transduction when the two were codelivered into the mouse. Based on these data, authors propose that species–specific interactions of AAVs with blood proteins may differentially impact vector distribution and efficacy in different experimental models.

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