Comparison of Timothy grass pollen extract- and single major allergen-induced gene expression and mediator release in airway epithelial cells: a meta-analysis
Clinical & Experimental Allergy, 05/24/2012
Roschmann KIL et al. – Additional components within extract of Timothy grass pollen (GPE) and the resulting modulation of general processes affecting gene transcription and signalling pathways might be crucial to maintain/overcome the diseased phenotype and to induce the influx of cells contributing to late–phase allergic responses. When the initial process of sensitization is the matter of interest or late–phase allergic responses one might miss important immune modulatory molecules and their interaction with allergens by applying single components only.