Risk of hip fracture associated with hepatitis C virus infection and hepatitis C/HIV Coinfection
Re VL et al. – Among Medicaid enrollees, Hepatitis C virus (HCV)/human immunodeficiency virus (HIV) coinfection was associated with increased rates of hip fracture compared to HCV–monoinfected, HIV–monoinfected, and HCV/HIV–uninfected persons. HCV–monoinfected patients had an increased risk of hip fracture compared to uninfected individuals.Methods
- The authors conducted a cohort study in 36,950 HCV/HIV-coinfected, 276,901HCV-monoinfected, 95,827 HIV-monoinfected, and 3,110,904 HCV/HIV-uninfected persons within the U.S. Medicaid populations of California, Florida, New York, Ohio, and Pennsylvania (1999-2005).
- Incidence rates of hip fracture were lowest among uninfected persons (1.29 events/1000 person-years), increased with the presence of either HIV infection (1.95 events/1000 person-years) or HCV infection (2.69 events/1000 person-years), and were highest among HCV/HIV-coinfected individuals (3.06 events/1000 person-years).
- HCV/HIV coinfection was associated with an increased relative hazard (adjusted hazard ratio [95% confidence interval]) of hip fracture compared to HCV-monoinfected (1.38 [1.25-1.53]), HIV-monoinfected (females: 1.76 [1.44-2.16]; males: 1.36 [1.20-1.55]), and uninfected persons (females: 2.65 [2.21-3.17]; males: 2.20 [1.97-2.47]).
- HCV monoinfection was associated with an increased risk of hip fracture compared to uninfected individuals, and the relative increase was highest in the youngest age groups (females, 18-39 years: 3.56 [2.93-4.32]; males, 18-39 years: 2.40 [2.02-2.84]).