Elevated plasma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock
Critical Care,  Clinical Article

Linder A et al. – Plasma heparin–binding protein (HBP) levels were significantly higher in patients with severe sepsis or septic shock compared to patients with non–septic illness in the intensive care unit (ICU). HBP was associated with severity of disease, and an elevated HBP at admission was associated with an increased risk of death. HBP that rises over time may identify patients with a deteriorating prognosis. Thus, repeated HBP measurement in the ICU may help monitor treatment and predict outcome in patients with severe infections.

Methods
  • A prospective study of two patient cohorts treated in the ICU at Karolinska University Hospital Huddinge in Sweden.
  • 179 patients were included, of whom 151 had sepsis (126 with septic shock and 25 patients with severe sepsis) and 28 a non–septic critical condition.
  • Blood samples were collected at five time points during six days after admission.

Results
  • HBP levels were significantly higher in the sepsis group as compared to the control group.
  • At admission to the ICU, a plasma HBP concentration of [greater than or equal to]15ng/mL and/or a HBP(ng/mL) / White blood cell count (109/L) ratio of >2 was found in 87.2% and 50.0% of critically ill patients with sepsis and non–septic illness, respectively.
  • A lactate level of >2.5mmol/L was detected in 64.9% and 56.0% of the same patient groups.
  • Both in the sepsis group (n=151) and in the whole group (n=179), plasma HBP concentrations at admission and in the last measured sample within the 144hour study period were significantly higher among 28–day non–survivors as compared to survivors, and in the sepsis group, an elevated HBP–level at baseline was associated with an increased case–fatality rate at 28days.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Infectious Disease

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Infectious Disease Articles

1 Duke team brings life-saving function to ketchup packets Duke University Health & Medicine News, July 3, 2014

2 Colistin for the treatment of ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: A systematic review and meta-analysis International Journal of Antimicrobial Agents, October 7, 2014    Evidence Based Medicine    Review Article

3 Association of chronic hepatitis C infection with T-cell phenotypes in HIV-negative and HIV-positive women Journal of Acquired Immune Deficiency Syndromes, October 24, 2014    Clinical Article

4 Narcolepsy and influenza A(H1N1) pandemic 2009 vaccination in the United States Neurology®, October 24, 2014    Evidence Based Medicine    Clinical Article

5 A systematic review: Can one prescribe carbapenems to patients with IgE-mediated allergy to penicillins or cephalosporins? Clinical Infectious Diseases, October 6, 2014    Review Article

6 Long-term use of antibiotics and proton pump inhibitors predict development of infections in patients with cirrhosis Clinical Gastroenterology and Hepatology , September 19, 2014    Clinical Article

7 Rosuvastatin preserves renal function and lowers cystatin C in HIV-infected subjects on antiretroviral therapy: The SATURN-HIV Trial Clinical Infectious Diseases, August 15, 2014    Clinical Article

8 Antimicrobial lock solutions as a method to prevent central line-associated bloodstream infections: A meta-analysis of randomized controlled trials Clinical Infectious Diseases, October 20, 2014    Evidence Based Medicine    Clinical Article

9 Colistin for the treatment of ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: A systematic review and meta-analysis International Journal of Antimicrobial Agents, August 11, 2014    Evidence Based Medicine    Review Article

10 Antistaphylococcal penicillins versus cephalosporins for definitive treatment of methicillin-susceptible bacteraemia: A systematic review and meta-analysis International Journal of Antimicrobial Agents, September 30, 2014    Evidence Based Medicine    Review Article

11 Topical vancomycin in combination with perioperative antibiotics and tight glycemic control helps to eliminate sternal wound infections The Journal of Thoracic and Cardiovascular Surgery, July 17, 2014    Clinical Article

12 Did CDC's 2006 revised HIV testing recommendations make a difference? evaluation of HIV testing in the US household population, 2003–2010 Journal of Acquired Immune Deficiency Syndromes, October 16, 2014    Clinical Article

13 Salvage combination antifungal therapy for acute invasive aspergillosis may improve outcomes: A systematic review and meta-analysis International Journal of Infectious Diseases, September 22, 2014    Evidence Based Medicine    Review Article

14 Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: An update of data from a randomised, double-blind, phase 3 trial The Lancet Infectious Diseases, October 8, 2014    Clinical Article

15 California trees nailed as the source of mystery infections Duke University Health & Medicine News, August 26, 2014

16 A meta-analysis comparing the efficacy of entecavir and tenofovir for the treatment of chronic hepatitis B infection The Journal of Clinical Pharmacology, October 9, 2014    Evidence Based Medicine    Review Article

17 HPV and lung cancer risk: A meta-analysis Journal of Clinical Virology, October 22, 2014    Evidence Based Medicine

18 Effectiveness of a dental care intervention in the prevention of lower respiratory tract nosocomial infections among intensive care patients: A randomized clinical trial Infection Control and Hospital Epidemiology, October 24, 2014    Clinical Article

19 Antimicrobial lock solutions as a method to prevent central line-associated bloodstream infections: A meta-analysis of randomized controlled trials Clinical Infectious Diseases, August 27, 2014    Evidence Based Medicine    Clinical Article

20 Clinical management of staphylococcus aureus bacteremia: a review JAMA, October 1, 2014    Evidence Based Medicine    Review Article    Clinical Article

Indexed Journals in Infectious Disease: Journal of Infection, AIDS, American Journal of Infection Controlmore