Preexisting Adenovirus Seropositivity is Not Associated with Increased HIV-1 Acquisition in Three HIV-1 Vaccine Efficacy Trials

The Journal of Infectious Diseases, 05/10/2012

Authors therefore investigated whether preexisting Ad seropositivity to 7 different Ad serotypes was associated with increased risk of HIV–1 infection in 3 HIV–1 vaccine efficacy trials. In a case–control study involving 1570 adults enrolled in the VAX003 and VAX004 trials of a recombinant protein subunit HIV–1 vaccine and in the Step study, they observed that preexisting seropositivity to multiple Ad serotypes was not intrinsically associated with increased risk of HIV–1 acquisition.

Print Article Summary