The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010
Alimentary Pharmacology and Therapeutics,  Clinical Article

Musumba C et al. – The non–steroidal anti–inflammatory drug (NSAID), particularly low–dose aspirin (LDA), were most commonly associated with peptic ulcer disease (PUD) in this cohort. The findings are compatible with the decline in the prevalence of H. pylori–positive PUD and increase in non–NSAID, non–H. pylori PUD previously reported.

Methods
  • Patients diagnosed with PUD following endoscopy were categorised as non-steroidal anti-inflammatory drug (NSAID)-users or non-users, and their H. pylori status determined.
  • Comparisons between NSAID-users and non-users, and between non-aspirin NSAID-users and LDA-users were summarised using counts and corresponding percentages (for categorical variables) and means and standard deviations (for continuous variables).

Results
  • Overall, 386 patients were enrolled; 57% used NSAIDs (51% LDA only) and 43% were non-users.
  • 57% of the whole cohort was H. pylori-positive (including 66% with duodenal ulcers and 47% with gastric ulcers).
  • Compared with non-users, NSAID-users were older (mean age 68 vs. 61 years) and fewer were H. pylori-positive (52% vs. 63%).
  • LDA-users were older (mean age 71 vs. 62 years) and more likely to be H. pylori-positive (61% vs. 41%) than those using non-aspirin NSAIDs.
  • Twelve per cent of the patients were neither using NSAIDs nor were H. pylori-positive.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Infectious Disease

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Infectious Disease Articles

1 Inhaled Ebola vaccine may offer long-term protection from virus The University of Texas at Austin News, November 7, 2014

2 Antibiotics get a time-out McGill University Health Centre News, November 20, 2014

3 Duke team brings life-saving function to ketchup packets Duke University Health & Medicine News, July 3, 2014

4 Colistin for the treatment of ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: A systematic review and meta-analysis International Journal of Antimicrobial Agents, October 7, 2014    Evidence Based Medicine    Review Article

5 Triatoma sanguisuga blood meals and potential for Chagas disease, Louisiana, USA Full Text Emerging Infectious Diseases, November 25, 2014    Free full text    Clinical Article

6 A systematic review: Can one prescribe carbapenems to patients with IgE-mediated allergy to penicillins or cephalosporins? Clinical Infectious Diseases, October 6, 2014    Review Article

7 Effectiveness of silver-impregnated central venous catheters for preventing catheter-related blood stream infections: A meta-analysis International Journal of Infectious Diseases, November 11, 2014    Evidence Based Medicine

8 Prolonged infusion versus intermittent boluses of β-lactam antibiotics for treatment of acute infections: A meta-analysis International Journal of Antimicrobial Agents, April 25, 2014    Review Article

9 Condoms are more effective when applied by males: a study of young black males in the United States Annals of Epidemiology , November 14, 2014    Clinical Article

10 Prediction model for 30-day hospital readmissions among patients discharged receiving outpatient parenteral antibiotic therapy Clinical Infectious Diseases, January 30, 2014    Clinical Article

11 Antibody persistence after primary and booster doses of a quadrivalent meningococcal conjugate vaccine in adolescents The Pediatric Infectious Disease Journal, October 31, 2014    Clinical Article

12 Adherence to HIV postexposure prophylaxis: A systematic review and meta-analysis AIDS, November 21, 2014    Evidence Based Medicine    Review Article

13 Antistaphylococcal penicillins versus cephalosporins for definitive treatment of methicillin-susceptible bacteraemia: A systematic review and meta-analysis International Journal of Antimicrobial Agents, September 30, 2014    Evidence Based Medicine    Review Article

14 Diagnostic accuracy of IL-2 for the diagnosis of latent tuberculosis: A systematic review and meta-analysis European Journal of Clinical Microbiology & Infectious Diseases, November 17, 2014    Evidence Based Medicine    Review Article

15 HIV: New drugs, new guidelines Current Opinion in Infectious Diseases, November 5, 2014    Review Article

16 Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: A randomized clinical trial JAMA, August 1, 2014    Clinical Article

17 Effectiveness of seasonal influenza vaccine in community-dwelling elderly people: A meta-analysis of test-negative design case-control studies The Lancet Infectious Diseases, November 7, 2014    Evidence Based Medicine

18 Prevalence, correlates, and outcomes of cryptococcal antigen positivity among AIDS patients, United States from 1986-2012 Clinical Infectious Diseases, November 26, 2014    Clinical Article

19 Global burden of transmitted HIV drug resistance and HIV-exposure categories: A systematic review and meta-analysis AIDS, November 24, 2014    Evidence Based Medicine    Review Article

20 Association between footwear use and neglected tropical diseases: A systematic review and meta-analysis Full Text PLoS Neglected Tropical Diseases, November 19, 2014    Free full text    Evidence Based Medicine    Review Article

Indexed Journals in Infectious Disease: Journal of Infection, AIDS, American Journal of Infection Controlmore