Use of interferon-gamma release assays in a health care worker screening program: Experience From a tertiary care centre in the United States
Canadian Respiratory Journal, 04/24/2012
Joshi M et al. – The QuantiFERON–TB Gold In–Tube test (QFT–GIT) test is feasible in large health care setting as an alternative to tuberculin skin test (TST) for M tuberculosis infection screening in HCWs but is not free from challenges. The major concerns are the high number of positive test results and high reversion rates on repeat testing, illustrating poor short–term reproducibility of positive QFT–GIT test results. These results suggest adopting a borderline zone between interferon–gamma values of 0.35 IU/mL to 2.0 IU/mL, and cautious clinical interpretation of values in this range.