Helicobacter pylori-Associated Regulation of Forkhead Transcription Factors FoxO1/3a in Human Gastric Cells

Helicobacter, 05/08/2012

Forkhead transcription factors of class O (FoxO)1 and FoxO3a are novel nuclear substrates of H. pylori–induced phosphoinositide–3 kinase (PI3K)/Akt cell survival signaling pathways that partially control interleukin–8 production. OipA–regulated interleukin–8 release through PI3K/Akt is dependent on FoxO1/3a inactivation, whereas cag PAI–mediated interleukin–8 production employs FoxO1/3–independent signaling.

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