Efficient Nef-Mediated Downmodulation of TCR-CD3 and CD28 Is Associated with High CD4+ T Cell Counts in Viremic HIV-2 Infection
Journal of Virology, 04/13/2012
Khalid M et al. – Taken together, the data suggest that the efficient Nef–mediated downmodulation of TCR–CD3 and CD28 help viremic HIV–2–infected individuals to maintain normal CD4+ T cell homeostasis by preventing T cell activation and by suppressing the induction of death receptors that may affect the functionality and survival of both virally infected and uninfected bystander cells.



