Risk of tuberculosis reactivation with tofacitinib (cp-690550) Full Text
The Journal of Infectious Diseases, 04/09/2012
Maiga M et al. – The goal was to characterize the impact of tofacitinib on LTBI using a mouse model of contained TB. The data indicate that tofacitinib reduces host containment of M.tb. and promotes bacterial replication in the lungs, suggesting TB reactivation. Tofacitinib may carry a significant risk for LTBI reactivation in humans.