New therapies for pneumonia
Current Opinion in Pulmonary Medicine, 03/29/2012
Ricard JD – Several leads have been investigated, targeting adhesion, communication, toxins, virulence factors, direct bacterial killing by bacteriophages, and vaccine strategies. Promising results have been obtained with these different targets, including inhibition of quorum sensing, use of pilicide compounds to inhibit bacterial adhesion, prevention and treatment of Pseudomonas aeruginosa pneumonia by bacteriophages, effective protection against P. aeruginosa lung infection with mucosal vaccination, use of anti–PcrV antibodies in P. aeruginosa–induced sepsis. Expectations are high regarding the translation of these experimental results into true clinical benefits for the patients.