Is Cefazolin Inferior to Nafcillin for Treatment of Methicillin-Susceptible Staphylococcus aureus Bacteremia
Antimicrobial Agents and Chemotherapy, 10/24/2011
Lee S et al. – Treatment failure was defined as a composite outcome of a change of antibiotics due to clinical failure, relapse, and mortality. Of 133 patients, 41 patients from each group were matched by propensity scores. There were no significant differences in baseline characteristics between the matched groups. The treatment failure rates were not significantly different at 4 or 12 weeks versus 10% at 4 weeks and 15% versus 15% at 12 weeks. Cefazolin treatment was interrupted less frequently than nafcillin treatment due to drug adverse events. Cefazolin had clinical efficacy similar to that of nafcillin and was more tolerable than nafcillin for the treatment of Methicillin–Susceptible Staphylococcus aureus bacteremia.