Diagnosis of tuberculosis infection by tuberculin skin test and a whole-blood interferon-gamma release assay in patients considered for anti-tumor necrosis factor-alpha therapy
Diagnostic Microbiology and Infectious Disease, 08/23/2011
Casas S et al. – QuantiFERON–TB Gold in–Tube (QFT–GIT) is useful for identifying immune–mediated inflammatory diseases patients requiring treatment of latent tuberculosis before anti–tumor necrosis factor therapy. However, given the poor agreement between tuberculin skin test and QFT–GIT, authors advocate a strategy of simultaneous testing to optimize diagnostic sensitivity.