Pre-Steady-State Kinetic Analysis of the Incorporation of Anti-HIV Nucleotide Analogs Catalyzed by Human X- and Y-Family DNA Polymerases
Antimicrobial Agents and Chemotherapy, 01/06/2011
Brown JA et al. – The authors kinetic results suggest nucleoside reverse transcriptase inhibitor insertion catalyzed by human X– and Y–family DNA polymerases is a potential mechanism of nucleoside reverse transcriptase inhibitor drug toxicity, and they have established a structure–function relationship for designing improved nucleoside reverse transcriptase inhibitors.






