Experimental Dengue Virus Challenge of Human Subjects Previously Vaccinated with Live-Attenuated Tetravalent Dengue Virus Vaccines

The Journal of Infectious Diseases, 12/24/2012

Protection against dengue requires immunity against all 4 serotypes of virus. Experimental challenge may be useful in evaluating vaccine–induced immunity. Vaccination with live–attenuated TDV induced variable protection against s.c. challenge. DENV–3 experimental challenge was associated with transient but significant hepatitis.

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