Altered Circulating Levels of Matrix Metalloproteinases and Inhibitors Associated with Elevated Type 2 Cytokines in Lymphatic Filarial Disease

PLoS Neglected Tropical Diseases, 06/12/2012

The data therefore suggest that while filarial lymphatic disease is characterized by a non–specific increase in plasma MMPs and TIMPs, the balance between MMPs and TIMPs is an important factor in regulating tissue pathology during active infection.

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