A novel acyclic oligomycin A derivative formed via retro-aldol rearrangement of oligomycin A

The Journal of Antibiotics, 05/25/2012

The derivative virtually lost the inhibitory activity against F0F1 ATP synthase–containing proteoliposomes, strongly suggesting the existence of the target(s) beyond F0F1 ATP synthase that is important for the antitumor potency of oligomycin A.

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