The Combination of Doripenem and Colistin Is Bactericidal and Synergistic against Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae

Antimicrobial Agents and Chemotherapy, 05/17/2012

Among colistin– and pan–drug–resistant isolates, synergy was identified in 60 and 67%, respectively. All other combinations were inferior. Authors are currently evaluating the combination of doripenem and colistin as a frontline therapy for KPC infection.

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