Evaluation of Standard- and High-Dose Daptomycin versus Linezolid against Vancomycin-Resistant Enterococcus Isolates in an In Vitro Pharmacokinetic/Pharmacodynamic Model with Simulated Endocardial Vegetations

Antimicrobial Agents and Chemotherapy, 05/17/2012

Daptomycin displayed a dose–dependent response against three VRE isolates, with high–dose daptomycin producing sustained bactericidal activity. Further research is warranted.

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