Antibacterial activity of statins: a comparative study of Atorvastatin, Simvastatin, and Rosuvastatin

Annals of Clinical Microbiology and Antimicrobials, 05/09/2012

Masadeh M et al. – The findings might raise the possibility of a potentially important antibacterial class effect for statins especially, atorvastatin and simvastatin.

Methods

  • Minimum inhibitory concentrations (MIC) values were evaluated and compared among three members of the statins drug (atorvastatin, simvastatin, and rosuvastatin).

Results

  • It was revealed that statins are able to induce variable degrees of antibacterial activity with atorvastatin, and simvastatin being the more potent than rosuvastatin.
  • Methicillin–sensitive staphylococcus aureus (MSSA), methicillin–resistant staphylococcus aureus (MRSA), vancomycin–susceptible enterococci (VSE), vancomycin–resistant enterococcus (VRE), acinetobacter baumannii, staphylococcus epidermidis, and enterobacter aerogenes, were more sensitive to both atorvastatin, and simvastatin compared to rosuvastatin.
  • On the other hand, escherichia coli, proteus mirabilis, and enterobacter cloacae were more sensitive to atorvastatin compared to both simvastatin and rosuvastatin.
  • Furthermore, most clinical isolates were less sensitive to statins compared to their corresponding standard strains.

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