Pegylated interferon-α induced hypoferremia is associated with the immediate response to treatment in hepatitis C
Hepatology, 05/07/2012Ryan JD et al.
Hepcidin induction occurs following the initiation of Pegylated interferon–α (PEG–IFNα) treatment for Hepatitis C virus (HCV), and is mediated via STAT3 signalling. The subsequent hypoferremia was greatest in those with the most significant decline in viral load, identifying systemic iron withdrawal as a marker of immediate interferon–α efficacy in HCV patients.
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