Nonstructural 5A protein of hepatitis C virus regulates heat shock protein 72 for its own propagation

Journal of Viral Hepatitis, 04/27/2012

Importantly, silencing of Hsp72 expression resulted in decrease in both RNA replication and virus production in HCV–infected cells. These data indicate that NS5A modulates Hsp72 via NFAT5 and reactive oxygen species activation for HCV propagation.

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