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Risk of tuberculosis reactivation with tofacitinib (cp-690550)

Maiga M et al. – The goal was to characterize the impact of tofacitinib on LTBI using a mouse model of contained TB. The data indicate that tofacitinib reduces host containment of M.tb. and promotes bacterial replication in the lungs, suggesting TB reactivation. Tofacitinib may carry a significant risk for LTBI reactivation in humans. [more...]