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Valacyclovir for Herpes Simplex Encephalitis

Pouplin T et al. – The authors report the penetration of acyclovir into the cerebrospinal fluid (CSF) in patients with HSE, treated with the oral prodrug valacyclovir at 1,000 mg three times daily. The oral therapy achieved adequate acyclovir concentrations in the CSF and may be an acceptable early treatment for suspected herpes simplex encephalitis (HSE) in resource–limited settings. [more...]

Antimicrobial Agents and Chemotherapy

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