Infectious Disease News Articles

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The latest Infectious Disease news articles, summarized and published daily to keep you current in today's news on bacterial infection, disease treatments, HIV/AIDS, hepatitis and clinical research in infectious diseases and more.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Sofosbuvir and ribavirin for hepatitis c in patients with hiv coinfection JAMA, July 30, 2014    Evidence Based Medicine    Clinical Article

2 Syphilis predicts HIV incidence among men and transgender women who have sex with men in a preexposure prophylaxis trial Clinical Infectious Diseases, July 30, 2014    Clinical Article

3 Effect on HPV vaccination in Japan resulting from news report of adverse events and suspension of governmental recommendation for HPV vaccination International Journal of Clinical Oncology, July 30, 2014    Clinical Article

4 Early initiation of combination antiretroviral therapy in HIV-1-infected newborns can achieve sustained virologic suppression with low frequency of CD4+ T cells carrying HIV in peripheral blood Clinical Infectious Diseases, July 30, 2014    Clinical Article

5 Difficulties in demonstrating superiority of an antibiotic for multidrug-resistant bacteria in nonrandomized studies Clinical Infectious Diseases, July 30, 2014    Clinical Article

6 The correlation between the presence of viremia and clinical severity in patients with enterovirus 71 infection: A multi-center cohort study Full Text BMC Infectious Diseases, July 30, 2014    Clinical Article

7 Impact of surveillance of hepatitis B and hepatitis C in patients with inflammatory bowel disease under anti-TNF therapies: Multicenter prospective observational study (REPENTINA 3) Journal of Crohn's and Colitis, July 30, 2014    Clinical Article

8 Real-life practice of antiviral therapy and disease patterns of patients with chronic hepatitis B: a single-center retrospective observation study Hepatology International, July 30, 2014    Clinical Article

9 High-concentration supplemental perioperative oxygen and surgical site infection following elective colorectal surgery for rectal cancer: a prospective, randomized, double-blind, controlled, single-site trial The American Journal of Surgery, July 30, 2014    Clinical Article

10 Molecular and ultrastructural characterization of Haplosporidium diporeiae n. sp., a parasite of Diporeia sp. (Amphipoda, Gammaridea) in the Laurentian Great Lakes (USA) Full Text Parasites & Vectors, July 30, 2014    Clinical Article

11 Impact of daily chlorhexidine baths and hand hygiene compliance on nosocomial infection rates in critically ill patients American Journal of Infection Control, July 30, 2014    Clinical Article

12 Sequential hand hygiene promotion contributes to a reduced nosocomial bloodstream infection rate among very low-birth weight infants: An interrupted time series over a 10-year period American Journal of Infection Control, July 30, 2014    Clinical Article

13 Inadequate vancomycin therapy in term and preterm neonates: a retrospective analysis of trough serum concentrations in relation to minimal inhibitory concentrations Full Text BMC Pediatrics, July 30, 2014    Clinical Article

14 sing crude whole genome assemblies of Neisseria gonorrhoeae as a platform for strain analysis: Clonal spread of gonorrhoea infection in Saskatchewan, Canada Journal of Clinical Microbiology, July 30, 2014    Clinical Article

15 Microbiological isolates and antibiotic sensitivities in culture-proven endophthalmitis: a 15-year review British Journal of Ophthalmology, July 30, 2014    Clinical Article

16 Preliminary outcomes of a pilot physical therapy program for HIV-infected patients with chronic pain AIDS Care, July 30, 2014    Clinical Article

17 Increasing provision of adolescent vaccines in primary care: A randomized controlled trial Pediatrics, July 30, 2014    Clinical Article

18 The RNA-dependent-RNA polymerase, an emerging antiviral drug target for the Hendra VI Current Drug Targets, July 30, 2014    Review Article

19 The effect of pathophysiology on pharmacokinetics in the critically ill patient - Concepts appraised by the example of antimicrobial agents Advanced Drug Delivery Reviews, July 30, 2014    Review Article

20 Prodromal illness before acute chest syndrome in pediatric patients with sickle cell disease Journal of Pediatric Hematology/Oncology, July 30, 2014    Clinical Article

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Highlights in Infectious Disease

Intermittent ?-lactam bolus therapy less effective than prolonged infusion

Based on a meta-analysis (n=29 studies [2206 patients]) published in the Journal of Antimicrobial Agents, intermittent β-lactam therapy was less effective than prolonged infusion with respect to mortality rate (RR = 0.66) and clinical success (RR = 1.12).

HIV viremia associated with increased risk for NHL

As reported in Modern Pathology, CDX2 expression is associated with low-grade small intestinal adenocarcinomas, decreased nodal metastases, and decreased perineural invasion, while MUC1 expression is associated with high-grade tumors, and nodular and infiltrative tumors. The CDX2+/MUC1- immunophenotype is associated with increased survival.

Hospital readmission rate in patients discharged on parenteral antibiotics

As reported in Clinical Infectious Diseases, the hospital readmission rate for patients (n=782) discharged on parenteral antibiotics was 26%. The mean patient age was 58 years. The leading diagnoses were bacteremia, osteomyelitis, and pyelonephritis. The indications for readmission included non-infection related (30%), worsening symptoms (29%), and new infections (19%). The ORs for readmission factors were as follows: each decade increase in age, 1.09; aminoglycoside use, 2.33; resistant organism, 1.57; and number of hospital discharges in prior 12 months, 1.20.

Other Topics in Infectious Disease

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