Chronic HCV infections are under-reported
As reported in Clinical Infectious Diseases, of 12M death certificates only one-fifth of the 0.5% of patients with HCV had HCV listed on the death certificate. Moreover, two-thirds of the patients had pre-mortem signs of chronic liver disease.
Intermittent ?-lactam bolus therapy less effective than prolonged infusion
Based on a meta-analysis (n=29 studies [2206 patients]) published in the Journal of Antimicrobial Agents, intermittent β-lactam therapy was less effective than prolonged infusion with respect to mortality rate (RR = 0.66) and clinical success (RR = 1.12).
Pre-treatment with EPA decreases incidence of IFN-?-induced depression
As reported in Biological Psychiatry, pre-treatment of HCV-infected patients (n=162) with EPA for 2 weeks resulted in a decreased incidence of IFN-α-induced depression at 24 weeks compared to placebo (10% vs. 30%), and a delayed onset of depression (12.0 weeks vs. 5.3 weeks).