1Clinical outcomes of first-line antiretroviral therapy in Latin America: Analysis from the LATINA retrospective cohort studyInternational Journal of STD & AIDS  Clinical Article
2Long-term efficacy of a hepatitis E vaccineNew England Journal of Medicine  Clinical Article  Evidence Based Medicine
3Trends in surgical site infections following orthopaedic surgeryCurrent Opinion in Infectious Diseases  Review Article
4Transmission risk behaviour at enrolment in participants in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trialHIV Medicine  Clinical Article
5Pulmonary function in an international sample of HIV-positive, treatment-na├»ve adults with CD4 counts >500 cells/μL: A substudy of the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trialHIV Medicine  Clinical Article
6Quantitative and qualitative antibody responses to immunization with the pneumococcal polysaccharide vaccine in HIV-infected patients after initiation of antiretroviral treatment: Results from a randomized clinical trialThe Journal of Infectious Diseases  Clinical Article
7Population pharmacokinetic analysis of raltegravir pediatric formulations in HIV-infected children 4 weeks to 18 years of ageThe Journal of Clinical Pharmacology  Clinical Article
8Pharmacokinetic interactions between telaprevir and antiretroviral drugs in HIV/HCV-coinfected patients with advanced liver fibrosis and prior HCV non-respondersInternational Journal of Antimicrobial Agents  Clinical Article
9Nosocomial bloodstream infections in a nationwide study: Comparison between solid organ transplant patients and the general populationTransplant Infectious Disease  Clinical Article
10Mechanical vs manual cleaning of hospital beds: A prospective intervention studyJournal of Hospital Infection  Clinical Article
1Transmission of hepatitis C virus associated with surgical procedures - New Jersey 2010 and Wisconsin 2011Morbidity and Mortality Weekly Report
2Measles vaccine in modified form also effective against Chikungunya virusMedical University of Vienna
3Pregnant women with asthma need to curb urge to ask for antibioticsAmerican College of Allergy, Asthma and Immunology News
4Respiratory viruses are main childhood pneumonia culprit: StudyVanderbilt University Medical Center Research News
5UMMS sequences hookworm genome; may lead to new treatments for tropical diseaseUniversity of Massachusetts Medical School News
6Infection control experts outline guidance for animal visitations in hospitalsThe Society for Healthcare Epidemiology of America News
7Gorilla origins of the last two AIDS virus lineages confirmedPenn Medicine
8New study details burden of C. diff in U.S.University of Rochester Medical Center
9Johns Hopkins researchers identify key to tuberculosis resistanceJohns Hopkins Medicine
10UV light from robots disinfects hospital roomsUniversity of Southern California Health News

Show Me:

Pre-treatment with EPA decreases incidence of IFN-?-induced depression

As reported in Biological Psychiatry, pre-treatment of HCV-infected patients (n=162) with EPA for 2 weeks resulted in a decreased incidence of IFN-α-induced depression at 24 weeks compared to placebo (10% vs. 30%), and a delayed onset of depression (12.0 weeks vs. 5.3 weeks).

Intermittent ?-lactam bolus therapy less effective than prolonged infusion

Based on a meta-analysis (n=29 studies [2206 patients]) published in the Journal of Antimicrobial Agents, intermittent β-lactam therapy was less effective than prolonged infusion with respect to mortality rate (RR = 0.66) and clinical success (RR = 1.12).

Hospital readmission rate in patients discharged on parenteral antibiotics

As reported in Clinical Infectious Diseases, the hospital readmission rate for patients (n=782) discharged on parenteral antibiotics was 26%. The mean patient age was 58 years. The leading diagnoses were bacteremia, osteomyelitis, and pyelonephritis. The indications for readmission included non-infection related (30%), worsening symptoms (29%), and new infections (19%). The ORs for readmission factors were as follows: each decade increase in age, 1.09; aminoglycoside use, 2.33; resistant organism, 1.57; and number of hospital discharges in prior 12 months, 1.20.

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Clinical Pearls

Clinical Pearl from Smartest DocPatients with IBD using anti-TNF therapy tend to have a low response to HBV vaccination.

Clinical Pearl from Smartest DocVitamin D level does not predict sustained virologic response to antiviral therapy in chronic HCV.

Clinical Pearl from Smartest DocAmphotericin B plus Flucytosin verbessert die Überlebenschancen von HIV-positiven Patienten mit Kryptokokken-Meningitis.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List