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T-cell activation promotes tumorigenesis in inflammation-associated cancer
Retrovirology, 12/18/09

Rauch D et al. – The authors demonstrated that activation of T–cells in T–cell receptor transgenic TAX–LUC animals dramatically exacerbated the development of subcutaneous TCR– CD16+ LGL tumors. The role of activated T–cells and acquired immunity in inflammation–associated cancers is broadly applicable to hematopoietic malignancies, and the authors propose these mice will be of use in dissecting mechanisms by which activated T–cells promote lymphomagenesis in vivo.

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