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Brunkhorst FM et al. – Sepsis treatment must focus on prevention of infection and on an optimized application of current antibiotic substances. The key factors are a broad spectrum, high dose and early initiation of treatment, a de–escalation strategy oriented to the clinical course supported by the application of novel molecular markers and, with exceptions, a limitation of treatment to 7–10 days. A closer cooperation between microbiologists, infection control specialists and clinical infectious disease consultants may be a key factor to overcome the dramatic problems of the future.

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