Infectious Dis. Medical News about Cathelicidins

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Cathelicidin peptide SMAP-29: comprehensive review of its properties and potential as a novel class of antibiotics
Drug Development Research, 11/03/09

Dawson RM et al. – The limitations of SMAP–29 are its high cytotoxicity and hemolytic activity, reduced activity under physiological conditions, and limited evidence for synergistic effects in combination with conventional antibiotics. Strategies with the potential to improve the selectivity toward pathogenic microorganisms over mammalian cells have been devised by the authors and are outlined.

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Glycoprotein 96-Mediated Presentation of Human Immunodeficiency...

The vitamin D–antimicrobial peptide pathway and its role in protection against infection
Future Microbiology, 11/18/09 Relevance Score: 80%

Neutrophil antimicrobial defense against Staphylococcus aureus is mediated by phagolysosomal but not extracellular trap-associated cathelicidin
Journal of Leukocyte Biology, 11/12/09 Relevance Score: 80%

Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils
European Journal of Immunology, 10/26/09 Relevance Score: 80%