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Functional characterization of Borrelia spielmanii outer surface proteins that interact with distinct members of the human factor H protein family and with plasminogen
Infection and Immunity, 10/30/09
Seling A et al. – Comparative sequence analysis of these protein alleles identified a single amino acid, histidine–79, as playing a significant role in CFH/CFHR1–binding, with substitution by an arginine completely abrogating ligand binding. The mutation of His–79 to Arg did not inhibit binding of plasminogen, another known ligand of this group of borrelial outer–surface proteins.
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