General Infectious Disease News Articles

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Dapp MJ et al. – The results reveal that the primary antiviral mechanism of 5–AZC can be attributed to its ability to increase the HIV–1 mutation frequency through viral–DNA incorporation during reverse transcription. The observations indicate that 5–AZC can affect two steps in HIV–1 replication (i.e., transcription and reverse transcription) but that its primary antiviral activity is due to incorporation during reverse transcription.

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