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Arginine Methylation Increases the Stability of Human Immunodeficiency Virus Type 1 Tat
Journal of Virology, 10/26/09
Sivakumaran H et al. – The data reveal a proteasome–dependent Tat degradation pathway that is inhibited by arginine methylation. The stabilizing action of PRMT6 could allow Tat to persist within the cell and the extracellular environment and thereby enable functions implicated in AIDS–related cancer, neurodegeneration, and T–cell death.
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