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See Latest ArticlesCleavage of IPS-1 in Cells Infected with Human Rhinovirus
Journal of Virology, 10/27/09
Drahos J et al. – The results suggest that IPS–1 is cleaved during HRV1a infection by three different proteases. Cleavage of IPS–1 may be a mechanism for evasion of the type I IFN response, leading to a more robust infection.
Vincent R. Racaniello, 10/27/09
| Infection of cultured cells by rhinovirus leads to very low induction of interferon. We carried out these studies to determine the reason for low interferon induction. The results indicate that a critical protein in the pathway leading to IFN induction, called IPS-1, is degraded during rhinovirus infection. Important follow-up questions to this work are: does cleavage of IPS-1 occur in the animal, and is this accompanied by reduced levels of IFN? Although rhinovirus infections are acute and self-limiting, they might be even shorter if a more robust IFN response took place. |
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