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Infection of neurons and encephalitis after intracranial inoculation of herpes simplex virus requires the entry receptor nectin-1
Proceedings of the National Academy of Sciences of the United States of America, 10/23/09
Kopp SJ et al. – These results contrast with recent findings that (i) either HVEM or nectin–1 can permit HSV infection of the vaginal epithelium in mice and (ii) nectin–1 is not the sole receptor capable of enabling spread of HSV infection from the vaginal epithelium to the PNS and CNS.
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