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See Latest ArticlesPhysiologic Cold Shock Increases Adherence of Moraxella catarrhalis to and Secretion of Interleukin 8 in Human Upper Respiratory Tract Epithelial Cells
The Journal of Infectious Diseases, 10/29/09
Spaniol V et al. – The authors show that a 26°C cold shock up-regulates the expression of UspA1, a major adhesin and putative virulence factor of M. catarrhalis, by prolonging messenger RNA half–life. Cold shock promotes M. catarrhalis adherence to upper respiratory tract cells via enhanced binding to fibronectin, an extracellular matrix component that mediates bacterial attachment. Exposure of M. catarrhalis to 26°C increases the outer membrane protein–mediated release of the proinflammatory cytokine interleukin 8 in pharyngeal epithelial cells.
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