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See Latest ArticlesA Human Domain Antibody and Lewisb Glycoconjugate That Inhibit Binding of Helicobacter pylori to Lewisb Receptor and Adhesion to Human Gastric Epithelium
The Journal of Infectious Diseases, 11/05/09
Younson J et al. – The poly?d?lysine?Leb hexasaccharide and an Leb human serum albumin conjugate not only inhibited adherence of H. pylori to gastric epithelium but also displaced adherent bacteria when added to human stomach sections. Combinations of Leb and sialyl Lex or domain antibody 25 and sialyl Lex acted synergistically. Domain antibody 25 inhibitor may have potential for prophylactic use and, in combination with Leb glycoconjugates, therapeutic use in treatment of drug?resistant H. pylori infection.
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