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See Latest ArticlesPopulation diversity and antibody selective pressure to Plasmodium falciparum MSP1 block2 locus in an African malaria-endemic setting
BMC Microbiology, 10/21/09
Noranate N et al. – The Pfmsp1 block2 locus presents a very large population sequence diversity. The lack of stable acquisition of novel antibody specificities despite exposure to novel allelic forms is reminiscent of clonal imprinting. The locus appears under antibody–mediated diversifying selection in a variable environment that maintains a balance between the various family types without selecting for sequence variant allelic forms.
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