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See Latest ArticlesThe pandemic 2009 (H1N1) swine influenza virus is mild compared to the pandemic 1918 (H1N1) virus because of a proline-to-serine substitution in the receptor-binding site of its hemagglutinin ? A hypothesis
Medical Hypotheses, 10/19/09
Padlan EA et al. – A proline–to–serine substitution could introduce a significant structural change in the receptor–binding site of the hemagglutinin, which could reduce the receptor–binding ability of the 2009 (H1N1) virus. It is proposed that this substitution is the cause of the relative avirulence of the 2009 (H1N1) virus compared to the 1918 (H1N1) virus.
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